Chemotherapy and radiation therapy can be used together as an adjuvant therapy. There are concerns about the use of chemotherapy because some chemotherapy regimens may suppress the activity of the immune system. Chemotherapy has also been tried for recurrent or metastatic disease. However, it only offers limited benefit with an average period of disease control of only approximately 90 days. As a consequence, chemotherapy is generally reserved for patients whose disease did not respond to immunotherapy see below , or to diminish symptoms palliative care of patients with advanced MCC who are no longer candidates for curative therapies.
Most people with recurrent or metastatic disease are recommended to undergo immunotherapy. Because these immunotherapy responses are very durable often lasting years , as compared to chemotherapy typically lasting months , these findings have quickly led to a preference for immunotherapy over chemotherapy for MCC. Based on the data from clinical trials, in , the U. In , these guidelines listed only chemotherapy as an option, in pembrolizumab was included, and in , avelumab, nivolumab, and pembrolizumab were all included with a preference that such immunotherapy be given prior to possible chemotherapy.
Pazopanib or imatinib, which are tyrosine kinase inhibitors, have shown some activity against Merkel cell carcinoma. More research is necessary to determine the long-term safety and effectiveness of these therapies for Merkel cell carcinoma and what role, if any, they may have in a treatment plan. All studies receiving U. Government funding, and some supported by private industry, are posted on this government web site. Merkel cell carcinoma, version 1.
Merkel cell carcinoma
J Natl Compr Canc Netw. Efficacy and safety of first-line avelumab treatment in patients with stage IV metastatic Merkel cell carcinoma: a preplanned interim analysis of a clinical trial.
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JAMA Oncol. Metastatic Merkel-cell carcinoma: the dawn of a new era. BMJ Case Rep.
Merkel cell carcinoma: Current S incidence and projected increases based on changing demographics. J Am Acad Dermatol. Clinical benefit from tyrosine kinase inhibitors in metastatic Merkel cell carcinoma: a case series of 5 patients. Am J Case Rep.
Merkel Cell Carcinoma - an overview | ScienceDirect Topics
Voelker R. Why Merkel cell cancer is garnering more attention. Merkel cell carcinoma.
Nat Rev Dis Primers. Real-world treatment outcomes in patients with metastatic Merkel cell carcinoma treated with chemotherapy in the USA. Future Oncol. Merkel cell carcinoma of the head and neck: recommendations for diagnostics and treatment. Ann Surg Oncol.
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Recent insights and advances in the management of Merkel cell carcinoma. J Oncol Pract. Response rates and durability of chemotherapy among 62 patients with metastatic Merkel cell carcinoma. Cancer Med. Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial. Lancet Oncol.
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Kline L, Coldiron B. Mohs micrographic surgery for the treatment of Merkel cell carcinoma. Dermatol Surg. PD-1 blockade with pembrolizumab in advanced Merkel-cell carcinoma.
go to link N Engl J Med. Retinoblastoma gene mutations detected by whole exome sequencing of Merkel cell carcinoma. Mod Pathol. Am J Clin Oncol. Merkel cell carcinoma: update and review.
Stages of Merkel Cell Carcinoma
Semin Cutan Med Surg. Merkel Cell Skin Cancer. Cutaneous neuroendocrine carcinoma. Orphanet Encyclopedia, July National Cancer Institute. May 2, Mayo Clinic for Medical Education and Research. Merkel Cell Carcinoma. March 7, Pathogenesis, clinical features, and diagnosis of Merkel cell carcinoma. UpToDate, Inc. Staging and treatment of Merkel cell carcinoma. Wells GL. Merck Manual Online Professional Version website. Updated February The content of the website and databases of the National Organization for Rare Disorders NORD is copyrighted and may not be reproduced, copied, downloaded or disseminated, in any way, for any commercial or public purpose, without prior written authorization and approval from NORD.
What is Merkel cell carcinoma?
NORD strives to open new assistance programs as funding allows. If we don't have a program for you now, please continue to check back with us. About News Events Contact. Synonyms of Merkel Cell Carcinoma cutaneous neuroendocrine carcinoma Merkel cell skin cancer MCC neuroendocrine carcinoma of the skin Merkel cell cancer. Introduction Endocrine tissue is specialized tissue that contains hormone-secreting cells. Causes Several risk factors have been established for MCC. Related Disorders Symptoms of the following diagnoses can be similar to those of Merkel cell carcinoma.
Diagnosis A diagnosis of Merkel cell carcinoma is based upon identification of characteristic symptoms, a detailed patient history, a thorough clinical evaluation, and a variety of specialized tests. Investigational Therapies Pazopanib or imatinib, which are tyrosine kinase inhibitors, have shown some activity against Merkel cell carcinoma. Years Published What You Need to Know. Risk Factors. How to spot a Merkel Cell Carcinoma.